PROF. CARLOS GONZÁLEZ RIVEROS. MV (UCHILE), MPHIL (UK), PHD (UK)
Biography
Dr. Carlos González is currently Full Professor of Andrés Bello University and Director of the School of Veterinary Medicine of the Andrés Bello University. He obtained a bachelor’s degree in Veterinary Sciences and a professional degree in Veterinary Medicine from the University of Chile and later completed a specialization program in Histopathology and Cytopathology in the Department of Experimental Medicine of the Faculty of Medicine of the University of Chile. He was awarded a scholarship by the British Council and Andes Foundation, to enroll at the Royal (Dick) School of Veterinary Medicine of the University of Edinburgh, Scotland, United Kingdom. There, he obtained a Master of Philosophy (MPhil) degree with a mention in immunopathology and later obtained the Doctor of Philosophy (PhD) degree with mention in immunopathology. After he returned and until 2007, he worked in the Department of Animal Pathology at the University of Chile, actively participating in undergraduate and postgraduate teaching, research and diagnostic service, in the area of Animal Pathology. At the same time, he has actively contributed to the development of diagnostic pathology in support of clinical activity, founding CITOVET, the first private laboratory specialized in veterinary diagnostic pathology. He also collaborates with state and private organizations in the area of Forensic Veterinary Pathology. He is a member of the postgraduate committee of the veterinary sciences area of the National Accreditation Commission (CNA), member of the Committee for Professional Certification and Specialties of the Pan American Council for Education in Veterinary Sciences (COPEVET), Past President of the Association of Accredited Veterinary Medicine Faculties and Schools of Chile (AFEVET) and presently is Representative for Latin America & The Caribbean at the Council for International Medical Education (CIVME) of The American Association of Veterinary Medical Collegues (AAVMC). He recently started to collaborate with the Sporotrichosis group of the Mycotic Diseases Branch Teams of the Centers for Disease Control and Prevention (CDC) USA.
Description of research interest
He began working on the development of hybridomas and monoclonal antibodies for the phenotyping and detection of macrophages, to later focus on the area of immunohistochemistry and computationally assisted morphometry. His area of research has focused mainly on Comparative Pathology studies. He has been mainly dedicated to the study of immunopathological aspects of inflammatory diseases and cancer, using experimental and clinical models. He has participated in several FONDECYT research projects, as principal investigator, co-investigator and collaborator. He also participates in other extramural and internal UNAB projects.
SEE SCIENTIFIC PUBLICATIONS AND PROFILE IN: https://scholar.google.com/citations?user=vWbI15QAAAAJ&hl=es
SCIENTIFIC PUBLICATIONS
Fierro-Arenas A, Landskron G, Camhi-Vainroj I, Basterrechea B, Parada-Venegas D, Lobos-González L, Dubois-Camacho K, Araneda C, Romero C, Domínguez A, Vásquez G, López-K F, Alvarez K, González CM, Hager Ribeiro C, Balboa E, Eugenin E, Hermoso MA, De la Fuente López M. 2024. Pannexin-1 expression in tumor cells correlates with colon cancer progression and survival. Aug 15:351:122851. doi: 10.1016/j.lfs.2024.122851. Epub 2024 Jun 17.
Aileen Dumont, Carlos Gonzalez, Belén Rivera, Isidora Mercy, Pamela Thomson, 2024. Challenging frontiers: Canine sporotrichosis due to Sporothrix brasiliensis, first case in Chile Medical Mycology Case Reports Volume 44, June https://doi.org/10.1016/j.mmcr.2024.100632
Pablo Cruces ; Benjamín Erranz , Agustín Pérez ; Sonia Reveco , Carlos González , Daniela Poblete , Jaime Retamal , Daniel E. Hurtado , and Franco Diaz. 2024 Non-Invasive CPAP Is a Lung- and Diaphragm-protective Approach in Self-inflicted Lung Injury Study Am J Respir Crit Care Med https://doi.org/10.1164/rccm.202309-1629LE
Pamela Thomson, Carlos González, Olivia Blank, Valentina Ramírez, Camila del Río, Sebastián Santibáñez, Pamela Pena. 2023 Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study, Journal of Fungi .9(2), 226; https://doi.org/10.3390/jof9020226.
Pablo Cruces, Benjamín Erranz, Carlos González, Franco Diaz 2022 Morphological Differences Between Patient Self-inflicted and Ventilator-induced Lung Injury. An Experimental Study Am J Respir Crit Care Med Mar 15;207(6):780-783 doi: 10.1164/rccm.202207-1360LE. Online ahead of print.
Gisela González Hein, Carlos González, Isabel Aguirr and Bernardo Huaracán 2022 Psittacinepox Virus in Psephotus Haematonotus (Red-Rumped Parrot) in Chile. Biomed J Sci & Tech Res Volume 45- Issue 2: 36381-36387 DOI: 10.26717/BJSTR.2022.45.007189.
Glauben Landskron, Karen Dubois-Camacho, Octavio Orellana-Serradell,Marjorie De la Fuente, Daniela Parada-Venegas, Mirit Bitrán, David Diaz-Jimenez, Shuang Tang , John A. Cidlowski , Xiaoling Li , Hector Molina, Carlos M. Gonzalez, Daniela Simian ,Jaime Lubascher, Victor Pola, Martín Montecino, Tjasso Blokzijl, Klaas Nico Faber, María-Julieta González, Rodrigo Quera and Marcela A. Hermoso. 2022 Regulation of the Intestinal Extra-Adrenal Steroidogenic Pathway Component LRH-1 by Glucocorticoids in Ulcerative Colitis Cells, 11(12):1905; https://doi.org/10.3390/cells11121905
Cruces P, Retamal J, Hurtado DE, Erranz B, Iturrieta P, González C, Díaz F. 2020 A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection. Crit Care. Aug 10;24(1):494. doi: 10.1186/s13054-020-03197-7.
Sonia Español-Jiménez, Constanza Abaud, Camila Aceituno, Mario Alvarado-Rybak, Cintya Borroni, Gustavo Chiang, Javier Díaz, Winfred Espejo, María Luisa Estay, Ana M. García-Cegarra, Carlos González, Belén Gutierrez, Josefina Gutierrez, Daniel Henríquez, Andrea Hirmas, Pamela Mejías, Constanza Meriño, Charity Molina,6Camilo Naretto, Florencia Olivares,, Patricia Pereira, Diego Peñaloza, Betsy Pincheira, Nicolás Pinto, Omar Rojas, Carolina Sánchez, Barbara Toro, Frederick Toro, and Raimundo Undurraga. 2020 First Genetic Record of a Strap-Toothed Beaked Whale (Mesoplodon layardii) Stranding in Chile Aquatic Mammals 46(6):542-548 DOI:10.1578/AM.46.6.2020.542
Carlos González, Andrés Espinoza 2019 Lymphocyte subpopulations and mast cells intestinal changes as indicators of inflammatory bowel disease in dogs. https://www.biorxiv.org/content/biorxiv/early/2019/08/02/723536.full.pdf
Camila Ahrednt; Diego Pérez-Venegas Mauricio Urbina; Carlos González; Pedro Echeveste; Marcela Aldana; José Pulgar;, Cristobal José Galbán-Malagón 2019 Nano-plastic ingestion cause histopathological intestinal lesions in an intertidal fish Marine Pollution Bulletin Volume 151 https://doi.org/10.1016/j.marpolbul.2019.110795
Sylvia Rojas‑Hucks, Arno C.Gutleb· Carlos M.González·2019 Servane Contal· Kahina Mehennaoui· An Jacobs· Hilda E. Witters· José Pulgar Xenopus laevis as a Bioindicator of Endocrine Disruptors in the Region of Central Chile Arch Environ Contam Toxicol. Oct;77(3):390-408. doi: 10.1007/s00244-019-00661-6. Epub 2019 Aug 17.
Alejandra Parra Pardo, Marcelo A. Gómez and Carlos M. González 2019 Cerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat . Open Veterinary Journal, (2019), Vol. 9(3): 246–252
Gabriela Del Aguila, Cristian G. Torres, Francisco R. Carvallo, Carlos M. Gonzalez, Federico F. Cifuentes 2019 Oral masses in African pygmy hedgehogs. J Vet Diagn Invest. 2019 Nov;31(6):864-867. doi: 10.1177/1040638719878870. Epub 2019 Oct 4.
Parra-Pardo, Alejandra; Gómez Jaramillo, Marcelo; Gonzalez, Carlos 2018 Cerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat Open Vet J. 2019 Jul-Sep; 9(3): 246–252.
Jorge C. Lohse, Enrique Paredes, Carlos M. Gonzalez, Marc Koene, Mahmoud Mageed.2018 Pyrrolizidine alkaloid toxicosis and hepatic encephalopathy in horses in Easter Island, Chile. Austral J. Vet. Sci. vol.50 .
Pablo Cruces, Camila Salas, Pablo Lillo, Tatiana Salomon, Felipe Lillo, Carlos González, Alejandro Pacheco, Daniel E. Hurtado. 2018 Renal decapsulation: A promising therapeutic approach to prevent ischemic AKI progression. Critical Care Medicine. 46(2):216-222
Gisela A. González-Hein, Carlos M. González, Bernardo R. Huaracán. 2017 Fatal dual infection of avian polyomavirus and psittacine beak and feather disease virus, Chile. Austral J. Vet. Sci. vol.49 (1):59-61.
Radial Osteochondroma in a Chilean Pure Breed Rodeo Horse: First Case Reported in this Breed. F Corrêa, D Parra, C González, F Lara. 2016 Sustainability Agri Food Enviromental Research, vol 4(4),.
Paula Abello-Cáceres; Javier Pizarro-Bauerle; Carlos Rosas; Ismael Maldonado; Lorena Aguilar-Guzmán; Carlos M González; Galia Ramìrez; Jorge Ferreira; Arturo Ferreira. 2016 Does Native Trypanosoma cruzi Calreticulin Mediates Growth Inhibition of a Mammary Tumor During Infection? BMC Cancer. 16:731
Luis E. Escobar, César Juarez, Gonzalo Medina-Vogel, Carlos M. Gonzalez. 2015 First Report on Bat Mortalities on Wind Farms in Chile Revista Gayana 79(1):11-17
González, R. Armisen, A. Stutzin y, P. Baez,, E. Landerer, R. Paredes. Contreras and C. Muñoz. 2014 Mast Cell Infiltration and Kit and Protease Expression During Progression of s Transgenic Prostate Cancer Murine Model (Tramp). Journal of Comparative Pathology 150 (1):88.
Candia, E.; Díaz-Jiménez, D; Farfán, N.; Langjahr, P.; Núñez, L.E.;de la Fuente, M.; López-Kostner, F.; Abedrapo, M.;Alvarez-Lobos, M.; Pineda, G.; Beltrán, C.J,; González, C.;,González, M.J.; Quera,R.; 2012 Hermoso, M. Increased Production of Soluble TLR2 Production by Lamina Propia Mononuclar Cells from Ulcerative Colitis Patients. Immunobiology. 2012 Jun;217(6):634-42.
Crossley, R; Coloma, A; Rios, C & Gonzalez, C. 2010 Determination of C-reactive protein in female dogs with benign and malignant mammary tumors. Arch Med Vet 42(1):101-105
Ribeiro CH, López NC, Ramírez GA, Valck CE, Molina MC, Aguilar L, Rodríguez M, Maldonado I, Martínez R, González C, Troncoso R, Lavandero S, Gingras AR, Schwaeble W, Ferreira A. 2009 Trypanosoma cruzi calreticulin: a possible role in Chagas’ disease autoimmunity. Molecular Immunology 46(6):1092-9
Fernandez, M. S., Arias, J. I., Gonzalez., A., Gonzalez, C., Saez, D., Arias, JL. 2008 Eggshell Membranes as a Bone Regeneration Inhibitor. Journal Of Tissue Engineering and Regenerative Medicine 2:228-235
González-Hein, G. González, C. Hidalgo, H.. 2008 An Avian Pox Outbreak in captive psittacine birds in Chile The Journal of Exotic Pet Medicine. 17(3):210-215
Lorena Salazar, Carlos González R., Paula Abello C,., Raquel Cepeda C., , Juan Carlos Aguillón G 2008. Modulation of Established Murine Collagen-Induced Arthritis by a Single Inoculation of Short-term Lipopolysaccharide-Stimulated Dendritic Cells. Annals of the Rheumatic Diseases. 67:1235-1241
González C., Abello P., Cepeda R., Salazar, L., Aguillón JC. 2007. Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen induced arthritis European Cytokine Network18(3):127-135.
Abello, L. Salazar, R. Cepeda, C. González, JC. 2006 Aguillón. Actividad angiogénica y apoptótica en la artritis murina inducida con colágeno bovino tipo II. Reumatología 2006; 22(3):116-118
Parraguez VH, M Atlagich, R Díaz, R Cepeda, C González, M De los Reyes, M E Bruzzone, C Behn y L Raggi. 2006. Ovine placenta at high altitudes: comparison of animals with different times of adaptation to hypoxic environment. Animal Reproduction Science 95: 151-157, 2006,
Flores, E.; Cattaneo, G.; González, C.; Cepeda, R.; Maureira,A.; Bastías,A. 2004 Canine trasmissible venereal tumor, clinical and macroscopical aspects under treatment with antineoplasic chemotherapy. International Journal Of Morphology 22(1):35
Toro, H., C. Gonzalez, C. Cerda, M.A. Morales, P.Dooner, & M. Salamero. 2002 Prevention of inclusion body hepatitis/hydropericardium syndrome in progeny chickens by vaccination of breeders with fowl adenovirus and chicken anemia virus. Avian Diseases, 46: 547-554.
Toro, H.; González , C.; Escobar, C.; Cerda, L.; Morales, M.A . 2001 Vertical induction of the inclusion body hepatitis/ hydropericardium syndrome witn fowl adenovirus and chicken anemia virus. Avian Diseases 45:215-222.
Gonzalez, CM, SM Griffey, DK Naydan, E Flores, R Cepeda, G. Cattaneo, BR Madewell 2000 Canine transmissible venereal tumour: a morphologic and immunohistochemical study of 11 tumours in growth phase and during regression following chemotherapy Journal of Comparative Pathology. 122 (4):241-248.
Toro, H.; González , C.; Reyes, E.; Cerda, L.; Geisse, C. and Hess M. 1999 Chicken anemia virus and fowl adenoviruses: association to induce the inclusion body hepatitis/ hydropericardium syndrome. Avian Diseases 44(1):51-58.
González, C; Flores, E; Cepeda, R.; Cattaneo, G.;Griffey, S.; Naydan; B & Madewell, B. 1999 Immunomorphometric charecterization of canine transmissible venereal tumor (Ctvt) in regression. Italian Journal of Anatomy and Embriology. 104: 235.
Toro, H.; Prusas, R.; Raue, L.; Cerda, C.; Geisse, C.; González, C. and Hess, M. 1998 Characterization of fowl adenoviruses from outbreaks of inclusion body hepatitis/hydropericardium syndrome in Chile. Avian Diseases Vol. 43:262-270.
González, Carlos; Flores, Estefanía; Cattaneo, Gino; Cepeda, Raquel; Lomardi, Cesar. 1998 Detección de antígenos asociados al tumor venéreo transmisible espontáneo del canino antes y durante la regresión inducida por quimioterapia. Archivos de Medicina Veterinaria Vol 30:289-290.
Flores, Estefanía; González, Carlos; Cattaneo, Gino; Lombardi, Cesar; Cepeda, Raquel. 1998 Tumor venéreo transmisible canino (TVT): Quimioterapia con Vincristina y repuesta general. Archivos de Medicina Veterinaria Vol 30:287-288.
| FROM | PROJECT | CODE | SOURCE | ||
| 1983 | 1986 | Study of the reproductive system of Coturnix coturnix japonica: Anatomical, histological and pathological aspects. | Co-Investigator | 1792 | DI* |
| 1984 | Alteration in the relative composition of glycosaminoglycans (GAGs) in neoplasms of domestic animals. | 1840155 | FONDECYT | ||
| 1985 | 1986 | Artificial management of goat lactation through hormonal systems. | Co-Investigator | A2212 | DI |
| 1988 | 1989 | Epidemiological study of domestic canine and feline tumors. | Collaborator | A2417 | DI |
| 1990 | 1992 | Virus for type 3 influenza in sheep: Isolation, characterization and pathological and immunopathological aspects of natural and experimental infection. | Main Investigator | 1047 | FONDECYT |
| 1991 | 1993 | Virus for type 3 influenza in sheep: Isolation, characterization and pathological and immunopathological aspects of natural and experimental infection. | Co-Investigator | A3246 | DI |
| 1994 | 1996 | Persistent in vitro infection of sheep alveolar macrophages with Para influenza type 3 virus: Expression of viral proteins on cell membrane. | IMain Investigator | A3516 | DI |
| 1997 | 1999 | Immunopathological aspects and tumor kinetics in canine transmissible venereal tumor, spontaneous and experimental, during its natural evolution and against treatment. | Main Investigator | 1970194 | FONDECYT |
| 1997 | 1998 | Avian adenoviruses and infectious anemia viruses: Interaction to induce hepatitis with inclusion bodies in birds. | Co-Investigator | 1970856 | FONDECYT |
| 1999 | 2000 | Prevention of hepatitis syndrome with inclusion bodies/hydropericardium through immunoprophylaxis against infectious anemia viruses and avian adenoviruses. | Co-Investigator | 1990816 | FONDECYT |
| 2002 | 2002 | Pathogens in Wild Birds Associated with Industrial Poultry Farming. | Co-Investigator | 1020607 | FONDECYT |
| 2002 | 2003 | Evaluation of Pulmonary Hemorrhage through Computational Morphometric Analysis of Bronchoalveolar Lavage of Fine Racing Blood Horses | Main Investigator | 3719-2 | FIV* |
| 2002 | 2004 | Tumor regression by inhibition of angiogenesis and induction of apoptosis: Computerized immunomorphometric analysis in a spontaneous neoplastic model of the canine. | Main Investigator | 1020980 | FONDECYT |
| 2004 | 2006 | Dendritic cell-mediated tolerogenic immunotherapy for the treatment of murine collagen-induced arthritis: initial phase for a possible treatment of rheumatoid arthritis. | Co-Investigator | 1040860 | FONDECYT |
| 2008 | 2009 | Comparative immunomorphometric study of intradermal mast cell density in atopic and neoplastic lesions and its association with angiogenic activity | Main Investigator | D- 11-08/R | Fondo Proyectos Internos-UNAB |
| 2010 | 2011 | Inflammatory Bowel Disease (IBD): Morphological and Immunophenotipic Comparative Study between an experimental TNBS mouse model and canine IBD. | Main Investigator | DI-29-10/R | Fondo Proyectos Internos-UNAB |
| 2009 | 2011 | Characterization of Possible Mechanisms of Tlr2 Processing and its Immunoregulatory Role in Inflammatory Bowel Disease | Collaborator | 1080290 | FONDECYT |
| 2008 | Center for Molecular Studies of the Cell | Collaborator | FONDAP | ||
| 2012 | 2014 | KIT receptor and proteases as targets to inhibit tumor growth and progression, associated with mast cell infiltration or malignancy | Main Investigator | 1121202 | FONDECYT |
| 2012 | 2014 | Mast cell infiltration as a prognostic marker in spontaneous human and canine prostate cancer and in transgenic adenocarcinoma of the mouse prostate (tramp) | Main Investigator | DI-164-12/R | Fondo Proyectos Internos-UNAB |
| 2013 | 2016 | Echinococcus granulosus strain are the determinant factor to hydatid cysts fertility? | Co-Investigator | 1130717 | FONDECYT |
| 2013 | 2015 | Acellular extracellular biomatrix of pig striated sphincter: A new strategy for the functional treatment of female stress urinary incontinence. | Co-Investigator | Fondo Proyectos Internos-UNAB Concurso NUCLEO | |
| 2014 | Establishment of a humanized mouse model of arthritis: An approach for studying autoimmune processes in vivo and testing novel therapeutic intervention strategies. Investigadora Principal: Dra. Katina Schinnerling. | Collaborator | 2014-2018 | Proyecto FONDECYT POST DOCTORADO | |
| 2019 | 2021 | Regulation of the intestinal extra-adrenal steroidogenic pathway component LRH-1 by glucocorticoids in ulcerative colitis Investigadora Principal: Dra. Landskron Ramos, Glauben Tamara Clinica Las Condes | Collaborator | 3190931 | Proyecto FONDECYT POST DOCTORADO |
| 2019 | 2022 | Evaluation of the immune profile and the expression of chemokines and their receptors in the colonic mucosa of dogs with Lymphoplasmacytic Colitis. Principal Investigator: Dra. Daniela Siel FAVET | Collaborator | 3190649. | Proyecto FONDECYT POST DOCTORADO |
| 2020 | 2021 | Injectable biotint based on salmon gelatin for the restoration of cartilage injuries. Dr. Javier Novoa Investigador responsable. Laboratorio de Medicina Nano-regenerativa, Facultad de Medicina, Universidad de los Andes. | Collaborator | 20CVID-128078 | Concurso Crea y Valida de CORFO |
| 2021 | 2022 | Organoleptic, toxicological, proximal chemical and histopathological characterization of degenerative pectoral myopathies in commercial birds: bases for a new regulation in condemnation. | Co Investigador | PM-PE-MPP-2021 | Proyecto Financiado por Conglomerado Empresarial CHILE.CARNE |
| 2021 | 2022 | Evaluation of the wound closure mechanism of the Dermoactiv agent Investigador Principal: Jaime Villegas | Co Investigador | DO-08-20/REG | Proyecto Interno Regular UNAB |
DI= Dirección de Investigación FIV=Fondos de Investigación Fac. Cs. Vet. U de Chile