Professor Carlos M González

   

Biography

Dr. Carlos González is currently Professor of Andrés Bello University and  Director of the School of Veterinary Medicine of the Andrés Bello University. He obtained a bachelor’s degree in Veterinary Sciences and a professional degree in Veterinary Medicine from the University of Chile and later completed a specialization program in Histopathology and Cytopathology in the Department of Experimental Medicine of the Faculty of Medicine of the University of Chile. He was awarded a scholarship by the British Council and Andes Foundation, to enroll at the Royal (Dick) School of Veterinary Medicine of the University of Edinburgh, Scotland, United Kingdom. There, he obtained a Master of Philosophy (MPhil) degree with a mention in immunopathology and later obtained the Doctor of Philosophy (PhD) degree with mention in immunopathology. After he returned and until 2007, he worked in the Department of Animal Pathology at the University of Chile, actively participating in undergraduate and postgraduate teaching, research and diagnostic service, in the area of ​​Animal Pathology. At the same time, he has actively contributed to the development of diagnostic pathology in support of clinical activity, founding Citovet, the first private laboratory specialized in veterinary diagnostic pathology.  He also collaborates with state and private organizations in the area of ​​Forensic Veterinary Pathology. He is a member of the postgraduate committee of the veterinary sciences area of ​​the CNA (National Accreditation Commission) and currently president of AFEVET (Association of Accredited Veterinary Medicine Faculties and Schools of Chile).

Description of research interest

He began working on the development of hybridomas and monoclonal antibodies for the phenotyping and detection of macrophages, to later focus on the area of ​​immunohistochemistry and computationally assisted morphometry. His area of ​​research has focused mainly on Comparative Pathology studies. He has been mainly dedicated to the study of immunopathological aspects of inflammatory diseases and cancer, using experimental and clinical models. He has participated in several FONDECYT research projects, as principal investigator, co-investigator and collaborator. He also participates in other extramural and internal UNAB projects.

SEE SCIENTIFIC PUBLICATIONS AND PROFILE IN: Andrés Bello University Researchers Portal

Glauben Landskron, Karen Dubois-Camacho, Octavio Orellana-Serradell,Marjorie De la Fuente, Daniela Parada-Venegas, Mirit Bitrán, David Diaz-Jimenez, Shuang Tang , John A. Cidlowski , Xiaoling Li , Hector Molina, Carlos M. Gonzalez, Daniela Simian ,Jaime Lubascher, Victor Pola, Martín Montecino, Tjasso Blokzijl, Klaas Nico Faber, María-Julieta González, Rodrigo Quera  and Marcela A. Hermoso. 2022 Regulation of the Intestinal Extra-Adrenal Steroidogenic Pathway Component LRH-1 by Glucocorticoids in Ulcerative Colitis  Cells11(12):1905; https://doi.org/10.3390/cells11121905

Cruces P, Retamal J, Hurtado DE, Erranz B, Iturrieta P, González C, Díaz F. 2020 A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection. Crit Care.  Aug 10;24(1):494. doi: 10.1186/s13054-020-03197-7.

Sonia Español-Jiménez, Constanza Abaud, Camila Aceituno, Mario Alvarado-Rybak, Cintya Borroni, Gustavo Chiang, Javier Díaz, Winfred Espejo, María Luisa Estay, Ana M. García-Cegarra, Carlos González, Belén Gutierrez, Josefina Gutierrez, Daniel Henríquez, Andrea Hirmas, Pamela Mejías, Constanza Meriño, Charity Molina,6Camilo Naretto, Florencia Olivares,, Patricia Pereira, Diego Peñaloza, Betsy Pincheira, Nicolás Pinto, Omar Rojas, Carolina Sánchez, Barbara Toro, Frederick Toro, and Raimundo Undurraga. 2020 First Genetic Record of a Strap-Toothed Beaked Whale (Mesoplodon layardii) Stranding in Chile  Aquatic Mammals 46(6):542-548 DOI:10.1578/AM.46.6.2020.542

Carlos González, Andrés Espinoza 2019 Lymphocyte subpopulations and mast cells intestinal changes as indicators of inflammatory bowel disease in dogs. https://www.biorxiv.org/content/biorxiv/early/2019/08/02/723536.full.pdf

Camila Ahrednt; Diego Pérez-Venegas Mauricio Urbina; Carlos González; Pedro Echeveste; Marcela Aldana; José Pulgar;, Cristobal José Galbán-Malagón 2019 Nano-plastic ingestion cause histopathological intestinal lesions in an intertidal fish Marine Pollution Bulletin Volume 151  https://doi.org/10.1016/j.marpolbul.2019.110795

Sylvia Rojas‑Hucks, Arno C.Gutleb· Carlos M.González·2019 Servane Contal· Kahina Mehennaoui· An Jacobs· Hilda E. Witters· José Pulgar  Xenopus laevis as a Bioindicator of Endocrine Disruptors in the Region of Central Chile   Arch Environ Contam Toxicol.  Oct;77(3):390-408. doi: 10.1007/s00244-019-00661-6. Epub 2019 Aug 17.

Alejandra Parra Pardo, Marcelo A. Gómez and Carlos M. González 2019 Cerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat .  Open Veterinary Journal, (2019), Vol. 9(3): 246–252

Gabriela Del Aguila, Cristian G. Torres, Francisco R. Carvallo, Carlos M. Gonzalez, Federico F. Cifuentes 2019 Oral masses in African pygmy hedgehogs. J Vet Diagn Invest. 2019 Nov;31(6):864-867. doi: 10.1177/1040638719878870. Epub 2019 Oct 4.

Parra-Pardo, Alejandra; Gómez Jaramillo, Marcelo; Gonzalez, Carlos 2018 Cerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat Open Vet J. 2019 Jul-Sep; 9(3): 246–252.

Jorge C. Lohse, Enrique Paredes, Carlos M. Gonzalez, Marc Koene, Mahmoud Mageed.2018  Pyrrolizidine alkaloid toxicosis and hepatic encephalopathy in horses in Easter Island, Chile. Austral J. Vet. Sci. vol.50 .

Pablo Cruces, Camila Salas, Pablo Lillo, Tatiana Salomon, Felipe Lillo, Carlos González, Alejandro Pacheco, Daniel E. Hurtado. 2018 Renal decapsulation: A promising therapeutic approach to prevent ischemic AKI progression. Critical Care Medicine. 46(2):216-222

Gisela A. González-Hein, Carlos M. González, Bernardo R. Huaracán. 2017  Fatal dual infection of avian polyomavirus and psittacine beak and feather disease virus, Chile. Austral J. Vet. Sci. vol.49 (1):59-61.

Radial Osteochondroma in a Chilean Pure Breed Rodeo Horse: First Case Reported in this Breed. F Corrêa, D Parra, C González, F Lara. 2016  Sustainability Agri Food Enviromental Research, vol 4(4),.

Paula Abello-Cáceres; Javier Pizarro-Bauerle; Carlos Rosas; Ismael Maldonado; Lorena Aguilar-Guzmán; Carlos M González; Galia Ramìrez; Jorge Ferreira; Arturo Ferreira. 2016 Does Native Trypanosoma cruzi Calreticulin Mediates Growth Inhibition of a Mammary Tumor During Infection? BMC Cancer. 16:731

Luis E. Escobar, César Juarez, Gonzalo Medina-Vogel, Carlos M. Gonzalez. 2015 First Report on Bat Mortalities on Wind Farms in Chile Revista Gayana 79(1):11-17

González, R. Armisen, A. Stutzin y, P. Baez,, E. Landerer, R. Paredes. Contreras and C. Muñoz. 2014 Mast Cell Infiltration and Kit and Protease Expression During Progression of s Transgenic Prostate Cancer Murine Model (Tramp). Journal of Comparative Pathology 150 (1):88.

Candia, E.; Díaz-Jiménez, D; Farfán, N.; Langjahr, P.; Núñez, L.E.;de la Fuente, M.; López-Kostner, F.; Abedrapo, M.;Alvarez-Lobos, M.; Pineda, G.; Beltrán, C.J,; González, C.;,González, M.J.; Quera,R.; 2012 Hermoso, M. Increased Production of Soluble TLR2 Production by Lamina Propia Mononuclar Cells from Ulcerative Colitis Patients.   Immunobiology. 2012 Jun;217(6):634-42.

Crossley, R; Coloma, A; Rios, C  &  Gonzalez, C. 2010 Determination of C-reactive protein in female dogs with benign and malignant mammary tumors. Arch Med Vet 42(1):101-105

Ribeiro CH, López NC, Ramírez GA, Valck CE, Molina MC, Aguilar L, Rodríguez M, Maldonado I, Martínez R, González C, Troncoso R, Lavandero S, Gingras AR, Schwaeble W, Ferreira A. 2009 Trypanosoma cruzi calreticulin: a possible role in Chagas’ disease autoimmunity. Molecular Immunology 46(6):1092-9

Fernandez, M. S., Arias, J. I.,  Gonzalez., A., Gonzalez, C.,  Saez, D.,  Arias, JL. 2008  Eggshell Membranes as a Bone Regeneration Inhibitor. Journal Of Tissue Engineering and Regenerative Medicine 2:228-235

González-Hein, G. González, C. Hidalgo, H.. 2008 An Avian Pox Outbreak in captive psittacine birds in Chile The Journal of Exotic Pet Medicine. 17(3):210-215

Lorena Salazar, Carlos González R., Paula Abello C,., Raquel Cepeda C., , Juan Carlos Aguillón G 2008. Modulation of Established Murine Collagen-Induced Arthritis by a Single Inoculation of Short-term Lipopolysaccharide-Stimulated Dendritic Cells. Annals of the Rheumatic Diseases. 67:1235-1241

González C., Abello P., Cepeda R., Salazar, L., Aguillón JC. 2007. Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen induced arthritis European Cytokine Network18(3):127-135.

Abello, L. Salazar, R. Cepeda, C. González, JC. 2006 Aguillón.Angiogenic and apoptotic activity in murine arthritis induced with bovine collagen type II. Reumatología 2006; 22(3):116-118

Parraguez VH, M Atlagich, R Díaz, R Cepeda, C González, M De los Reyes, M E Bruzzone, C Behn y L Raggi. 2006. Ovine placenta at high altitudes: comparison of animals with different times of adaptation to hypoxic environment. Animal Reproduction Science 95: 151-157, 2006,

Flores, E.; Cattaneo, G.; González, C.; Cepeda, R.; Maureira,A.; Bastías,A. 2004 Canine trasmissible venereal tumor, clinical and macroscopical aspects under treatment with antineoplasic chemotherapy. International Journal Of Morphology 22(1):35

Toro, H., C. Gonzalez, C. Cerda, M.A. Morales, P.Dooner, & M. Salamero. 2002 Prevention of inclusion body hepatitis/hydropericardium syndrome in progeny chickens by vaccination of breeders with fowl adenovirus and chicken anemia virus. Avian Diseases, 46: 547-554.

Toro, H.; González , C.; Escobar, C.; Cerda, L.; Morales, M.A . 2001  Vertical induction of the inclusion body hepatitis/ hydropericardium syndrome witn fowl adenovirus and chicken anemia virus.  Avian Diseases 45:215-222.

Gonzalez, CM, SM Griffey, DK Naydan, E Flores, R Cepeda, G. Cattaneo, BR Madewell 2000 Canine transmissible venereal tumour: a morphologic and immunohistochemical study of 11 tumours in growth phase and during regression following chemotherapy Journal of Comparative Pathology. 122 (4):241-248.

Toro, H.; González , C.; Reyes, E.; Cerda, L.; Geisse, C. and Hess M. 1999 Chicken anemia virus and fowl adenoviruses: association to induce the inclusion body  hepatitis/ hydropericardium syndrome.  Avian Diseases 44(1):51-58.

González, C; Flores, E; Cepeda, R.; Cattaneo, G.;Griffey, S.; Naydan; B & Madewell, B.  1999 Immunomorphometric charecterization of canine transmissible venereal tumor (Ctvt) in regression. Italian Journal of Anatomy and Embriology. 104: 235.

Toro, H.; Prusas, R.; Raue, L.; Cerda, C.; Geisse, C.; González, C. and Hess, M. 1998  Characterization of fowl adenoviruses from outbreaks of inclusion body hepatitis/hydropericardium syndrome in Chile. Avian Diseases Vol. 43:262-270.

González, Carlos; Flores, Estefanía; Cattaneo, Gino; Cepeda, Raquel; Lomardi, Cesar. 1998 Detection of canine spontaneous transmissible venereal tumor-associated antigens before and during chemotherapy-induced regression. Archivos de Medicina Veterinaria Vol 30:289-290.

Flores, Estefanía; González, Carlos; Cattaneo, Gino; Lombardi, Cesar; Cepeda, Raquel. 1998 Canine transmissible venereal tumor (TVT): Chemotherapy with Vincristine and general response. Archivos de Medicina Veterinaria Vol 30:287-288.

 

Research projects.

FROM PROJECT

 

CODE SOURCE
1983 1986 Study of the reproductive system of Coturnix coturnix japonica: Anatomical, histological and pathological aspects. Co-Investigator 1792 DI*
1984 Alteration in the relative composition of glycosaminoglycans (GAGs) in neoplasms of domestic animals. 1840155 FONDECYT
1985 1986 Artificial management of goat lactation through hormonal systems. Co-Investigator A2212 DI
1988 1989 Epidemiological study of domestic canine and feline tumors. Collaborator A2417 DI
1990 1992 Virus for type 3 influenza in sheep: Isolation, characterization and pathological and immunopathological aspects of natural and experimental infection. Main Investigator 1047 FONDECYT
1991 1993 Virus for type 3 influenza in sheep: Isolation, characterization and pathological and immunopathological aspects of natural and experimental infection. Co-Investigator A3246 DI
1994 1996 Persistent in vitro infection of sheep alveolar macrophages with Para influenza type 3 virus: Expression of viral proteins on cell membrane. IMain Investigator A3516 DI
1997 1999 Immunopathological aspects and tumor kinetics in canine transmissible venereal tumor, spontaneous and experimental, during its natural evolution and against treatment. Main Investigator 1970194 FONDECYT
1997 1998 Avian adenoviruses and infectious anemia viruses: Interaction to induce hepatitis with inclusion bodies in birds. Co-Investigator 1970856 FONDECYT
1999 2000 Prevention of hepatitis syndrome with inclusion bodies/hydropericardium through immunoprophylaxis against infectious anemia viruses and avian adenoviruses. Co-Investigator 1990816 FONDECYT
2002 2002 Pathogens in Wild Birds Associated with Industrial Poultry Farming. Co-Investigator 1020607 FONDECYT
2002 2003 Evaluation of Pulmonary Hemorrhage through Computational Morphometric Analysis of Bronchoalveolar Lavage of Fine Racing Blood Horses

 

 

Main Investigator 3719-2 FIV*
2002 2004 Tumor regression by inhibition of angiogenesis and induction of apoptosis: Computerized immunomorphometric analysis in a spontaneous neoplastic model of the canine. Main Investigator 1020980 FONDECYT
2004 2006  Dendritic cell-mediated tolerogenic immunotherapy for the treatment of murine collagen-induced arthritis: initial phase for a possible treatment of rheumatoid arthritis. Co-Investigator 1040860 FONDECYT
2008 2009 Comparative immunomorphometric study of intradermal mast cell density in atopic and neoplastic lesions and its association with angiogenic activity Main Investigator D- 11-08/R Fondo Proyectos Internos-UNAB
2010 2011 Inflammatory Bowel Disease (IBD): Morphological and Immunophenotipic Comparative Study between an experimental TNBS mouse model and canine IBD. Main Investigator DI-29-10/R Fondo Proyectos Internos-UNAB
2009 2011 Characterization of Possible Mechanisms of Tlr2 Processing and its Immunoregulatory Role in Inflammatory Bowel Disease Collaborator 1080290 FONDECYT
2008 Center for Molecular Studies of the Cell Collaborator FONDAP
2012 2014 KIT receptor and proteases as targets to inhibit tumor growth and progression, associated with mast cell infiltration or malignancy Main Investigator 1121202 FONDECYT
2012 2014 Mast cell infiltration as a prognostic marker in spontaneous human and canine prostate cancer and in transgenic adenocarcinoma of the mouse prostate (tramp) Main Investigator DI-164-12/R Fondo Proyectos Internos-UNAB
2013 2016 Echinococcus granulosus strain are the determinant factor to hydatid cysts fertility? Co-Investigator 1130717 FONDECYT
2013 2015 Acellular extracellular biomatrix of pig striated sphincter: A new strategy for the functional treatment of female stress urinary incontinence. Co-Investigator Fondo Proyectos Internos-UNAB Concurso NUCLEO
2014  Establishment of a humanized mouse model of arthritis: An approach for studying autoimmune processes in vivo and testing novel therapeutic intervention strategies. Investigadora Principal: Dra. Katina Schinnerling. Collaborator 2014-2018 Proyecto FONDECYT POST DOCTORADO

 

2019 2021 Regulation of the intestinal extra-adrenal steroidogenic pathway component LRH-1 by glucocorticoids in ulcerative colitis Investigadora Principal: Dra. Landskron Ramos, Glauben Tamara

Clinica Las Condes

Collaborator 3190931 Proyecto FONDECYT POST DOCTORADO

 

2019 2022 Evaluation of the immune profile and the expression of chemokines and their receptors in the colonic mucosa of dogs with Lymphoplasmacytic Colitis. Principal Investigator:  Dra. Daniela Siel FAVET Collaborator 3190649. Proyecto FONDECYT POST DOCTORADO

 

2020 2021 Injectable biotint based on salmon gelatin for the restoration of cartilage injuries. Dr. Javier Novoa Investigador responsable. Laboratorio de Medicina Nano-regenerativa, Facultad de Medicina, Universidad de los Andes. Collaborator 20CVID-128078 Concurso Crea y Valida de CORFO
2021 2022 Organoleptic, toxicological, proximal chemical and histopathological characterization of degenerative pectoral myopathies in commercial birds: bases for a new regulation in condemnation. Co Investigador PM-PE-MPP-2021 Proyecto Financiado por Conglomerado Empresarial CHILE.CARNE
2021 2022 Evaluation of the wound closure mechanism of the Dermoactiv agent

Investigador Principal: Jaime Villegas

Co Investigador DO-08-20/REG Proyecto Interno Regular UNAB

DI= Dirección de Investigación

FIV=Fondos de Investigación Fac. Cs. Vet. U de Chile